lated with surfactants and emulsifiers are reported to be superior in this regard (16). SEMI SOLID PREPARATION SUPPOSITORY PRESENTED BY MANOJ KUMAR M.PHARM (AMITY UNIVERSITY) Page 1. It is often possible to see drugs labelled “free sample, not for sale,” provided by medical representatives who sell the samples intended for doctors.The substandard drugs are often those in high demand for AIDS and malariaDrugs donated to charities are also often found in the street market. “Acidvalue”isbelow0.2 2. Dispensing of medications, 9th. changes in weather that can affect their quality. Nearly all the vendors are women, and more than a third are illiterate. Discuss … The delivery cars operate at night or early in the morning. Matrix-based slow release (SR) compressed propranolol HCl (25 mg) suppositories were formulated using PEG 4000 and either stearic acid or bees wax at different concentrations (5, 7.5 and 10%). *Density measurements done at 20° for those grades that are liquid at that temperature (300, 400, 600). Medicated topicals. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. Discuss about emulsifying agent 5. Suppositories 2 Marks. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. ** 10 Marks 3. Physical incompatibility 4. LWBK127-C24[291-297].qxd 10/19/2008 12:42 PM Page 296 Aptara Inc. iting step in drug release is not only the speed at which fatty bases melt or PEG bases dissolve but, also the time required for the drug to partition and diffuse out of the base into the rectal or vagi-, monitor the effectiveness of the drug deliv, methods for suppositories. Because cocoa butter has a variety of uses besides suppository making, it is r, Cocoa butter has a solidification temperature 12° to 13° below its melting point.This mak, Cocoa butter has the further disadvantage of existing in sev. 〈1151〉. These bases are fats, fixed oils, hydrocarbon or silicones. Remington: The science and practice of pharmacy. Base 1 is a good general-purpose, water-soluble suppository base. Classify and explain various dosage forms. Looks like you’ve clipped this slide to already. Define and classify dosage forms. This new business line is helped by the fact that the street sellers buy on a cash on delivery basis, while the legal pharmacists negotiate payments by credit. Source: The Dow Chemical Company, Carbowax and Carbowax Sentry Product Data Sheets (http://www. Give any four merits (advantages) of suppositories. In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Suppositories Mr. Pankaj Kusum Ramdas Khuspe M. Pharm (Pharmaceutics) 2. they are used as protectants, emollients , vehicles for hydrolysable drugs. 1. The relative bioavailability of propranolol (CAS 525-66-6) from three SR suppositories containing stearic acid, 7.5 and 10% and bees wax, 5%, was 86.4, 87.8, and 83.6% respectively. its melting point with drugs such as chloral hydrate. Chickenpox has many rare complications; transient synovitis is one of the very painful and self-limiting rare complications. In addition, some drugs made in Europe are in the street market—probably sold on by unscrupulous Europeans—even though domestic manufacturers are licensed to make the same drugs.The second category is the drugs found only in the illegal street markets. types of the general anesthesia maintenance (24 patients aged 20-52 years). It is claimed that suppositories and rectal retention enemas may give drug levels comparable to the intravenous injection provided an allowance is made for a 30-minute delay. Classify ointment bases and explain various method of compounding ointments. Also in this category are the illicit Chinese traditional medicines, a burgeoning market throughout the country. Short note- Methods of compounding of suppositories. the cocoa butter melt is given with example 31.1 in Chapter 31, release of some drugs.The release of a drug from a fatty suppositor, to the aqueous medium in the body cavity depends on the water/base partition coefficient, present in an ionized salt form, this can be a pr, drugs (these have high water/base partition coefficients) should be used when possible, such as phenobarbital is being incorporated into a cocoa butter suppository base, the. Suitable dosage forms are needed for protection of the drug from destructive influences of the atmospheric oxygen or moisture, for protection of drug from destruction from gastric acid on oral administration, to mask bitter taste and foul odor, to provide extended drug action through controlled release mechanism etc. Give any four merits (advantages) of suppositories. Define suppository. It is also one base that can be used for hand-molding suppositories; special molds or equipment are needed.These two properties make this base useful when a. custom suppository is needed on an emergency basis. Antiemetic drugs help ease nausea and vomiting. Discuss the Historical development of the Indian Pharmacopoeia. So, the weight of the suppository base is 14 – 3=11 gm. Pharmacopeial forum. 1. ANSWER. large proportion of insoluble ingredients. Schumacher GF. C. Emulsifying bases. Distinguish between lotions and liniments. Easton, PA: Mack Publishing Co., 1971; 849. because of the limited availability of natural cocoa butter, pounding materials in the United States have dev, nearly odorless and has a density of 0.95 to 0.98 at 20. and will absorb a small amount of water (4,8). Definition : The amount of drug(g) that displaces 1 gram of the base is called the displacement value of the drug. For insertion into body orifices where they melt, soften, or and... Oils, products of varying composition and melting temperatures ( e.g., Hydrogenated has the following table summarizes composition! To have results Pharm 1966 ; 23: 110 are easily controlled by appr 31... For this purpose be heated above 60°C Percolation process and Maceration process way to collect important slides you to! People and research you need to help your work the same temperatur some! Called a suppository base is 14 – 3=11 gm to sensitive membrane tissues means they... 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